Rejuran vs Profhilo vs skin boosters
Three injectables are sold as 'skin quality' treatments and are routinely confused. Polynucleotides (Rejuran) are a healing signal; Profhilo is a high-concentration hyaluronic acid that spreads and hydrates; conventional skin boosters are cross-linked micro-droplets of hyaluronic acid placed in the dermis.
Rejuran vs Profhilo vs skin boosters: which suits whom?
Profhilo and skin boosters for hydration and fine crepiness; polynucleotides for repair-type goals such as under-eye skin and post-acne skin; hybrid PDLLA products when a biostimulatory effect is wanted. All are courses, all need maintenance, and none lifts.
| Rejuran (PDRN) | Profhilo | Skin boosters | |
|---|---|---|---|
| What it is | Salmon-derived polynucleotides | Hybrid-complex hyaluronic acid | Cross-linked HA micro-droplets |
| Claimed action | Tissue repair signalling | Hydration and 'bio-remodelling' | Hydration and dermal plumping |
| Course | 3–4 sessions, 2–4 weeks apart | 2 sessions, 4 weeks apart | 2–3 sessions |
| Downtime | Papules for 1–3 days | Papules for hours to a day | Papules for 1–3 days |
| Evidence | Korean series; growing RCT base | Sponsored and independent small trials | Long clinical use; modest trials |
| HSA status | Registered as a medical device | Registered | Registered |
| Our verdict | Established | Established | Established |
By the numbers
- RCT
In a randomised trial of over 900 adults, daily sunscreen use slowed measurable skin ageing over four and a half years compared with discretionary use.
From the Collagen banking review — Sunscreen and prevention of skin aging: a randomized trial., Ann Intern Med, 2013. PMID 23732711.
“Profhilo and skin boosters for hydration and fine crepiness; polynucleotides for repair-type goals such as under-eye skin and post-acne skin; hybrid PDLLA products when a biostimulatory effect is wanted.”
The reviews behind this comparison
- PDRN and polynucleotidesThe injected courses are a sensible part of a skin plan; the salmon-sperm facial is mostly the microneedling doing the work.Established
- ProfhiloOne of the few injectables where 'natural' is built into the design.Established
- Skin boostersDull skin is a collagen problem — boosters hydrate the surface while collagen work happens underneath.Established
- Juvelook and PDLLA hybridsChoose the injector for restraint.Promising
- Collagen bankingA trend with a kernel of truth and a sales pitch wrapped around it. Daily sunscreen makes everything else work better; that is the only banking with a reliable return.Trend
How the vetted protocols use them
Questions
Which is better, Rejuran or Profhilo?
How long does Profhilo last?
Is the 'salmon sperm facial' the same as Rejuran?
Still deciding?
Ask us — or ask to be matched with a practitioner in Singapore who follows evidence-based treatment. The right choice is made at an in-person assessment, not from a table.
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