The 'O-Shot' and intimate PRP
PRP for sexual wellness · 'vampire' intimate treatments
The trademarked 'O-Shot' and its imitators are sold in med-spas and on Instagram as a 30-minute route to better orgasms and less leakage, riding the wider PRP 'vampire' branding.
The first proper trial arrived in 2026 and was a pilot; everything sold under this name before it was marketing with a syringe.
Reviewed against the Aesthetics International standard. Category: Regenerative.
Does The 'O-Shot' and intimate PRP work?
Caution. The first proper trial arrived in 2026 and was a pilot; everything sold under this name before it was marketing with a syringe. Thin and improving slowly.
- Verdict
- Caution Evidence, regulation or risk profile does not yet support routine use.
- Evidence base
- 3 PubMed-indexed studies cited below, including systematic reviews, randomised trials.
- Suits
- Possibly, within a research protocol or a gynaecologist's care, for a defined problem such as lichen sclerosus, dryness or mild stress incontinence after other options have been discussed.
- Not for
- 'Wellness' injections in women without a diagnosed problem, orgasmic difficulty that has not been assessed, or anyone sold a promised result.
- In Singapore
- PRP is prepared and injected by doctors in Singapore.
- Category
- Regenerative
- Reviewed
- 1 October 2026 by Aesthetics International. Revised as evidence and regulation change.
What it is
Platelet-rich plasma prepared from the patient's own blood and injected into the clitoris, the anterior vaginal wall near the urethra, or the labia. The 'O-Shot' is a trademarked protocol licensed to providers by its originator; most clinics offer a generic version.
How it works
Platelets release growth factors that in other tissues promote healing and blood vessel formation; the claim is that they do the same in genital tissue and improve sensitivity, lubrication and urethral support. Preparation systems, platelet concentration, volume and injection sites vary from clinic to clinic, which makes one 'O-Shot' hard to compare with another.
What the evidence says
Thin and improving slowly. A 2023 systematic review found only small prospective studies and one high-risk-of-bias trial, with improvements in questionnaire scores but no standard protocol; a 2026 systematic review of 18 studies reached the same conclusion. The first placebo-controlled randomised trial, published in 2026, was a 52-woman pilot in premenopausal women without severe dysfunction: PRP produced a larger rise in overall sexual function score than saline at six weeks, with the individual domains not significantly different and the effect smaller at six months. There is no evidence for 'intimate wellness' in women without a defined problem, and the original 2014 'O-Shot' pilot was 11 women.
What people are saying
Paraphrased from public discussion on TikTok, Instagram, Reddit and in the press. Not testimonials, and not about any one clinic. Reported in: healthline.com, plasticsurgery.org.
What the studies show
- RCT
A 52-woman single-blind pilot found a greater rise in total sexual function score after anterior vaginal wall PRP than saline at six weeks, with domain scores not significantly different and no serious adverse events.
Vaginal Injection of Platelet-Rich Plasma for Sexual Function: A Randomized Controlled Trial. — Obstet Gynecol, 2026. PMID 41855531.
- systematic review
Twelve mostly uncontrolled studies reported improved sexual function and incontinence scores after PRP, with the single randomised trial at high risk of bias and no standard protocol.
Efficacy and Safety of Platelet-Rich Plasma Injections for the Treatment of Female Sexual Dysfunction and Stress Urinary Incontinence: A Systematic Review. — Biomedicines, 2023. PMID 38001920.
- systematic review
Eighteen heterogeneous studies associated vulvovaginal PRP with symptomatic improvement and few adverse events, but small samples and variable protocols prevented firm conclusions.
Platelet-rich plasma in the management of vulvovaginal disorders: a systematic review. — J Sex Med, 2026. PMID 41168677.
Studies are selected for relevance and quality, not for agreement with the verdict; PubMed records are linked so the reader can check them.
Who it suits
Suits
Possibly, within a research protocol or a gynaecologist's care, for a defined problem such as lichen sclerosus, dryness or mild stress incontinence after other options have been discussed.
Not for
'Wellness' injections in women without a diagnosed problem, orgasmic difficulty that has not been assessed, or anyone sold a promised result.
Alternatives
The two reviewed treatments most often weighed against The 'O-Shot' and intimate PRP, on the same standard.
| The 'O-Shot' and intimate PRP | PRP 'vampire facial' | PRF and 'EZ Gel' | |
|---|---|---|---|
| Verdict | Caution | Promising | Promising |
| What it is | Platelet-rich plasma prepared from the patient's own blood and injected into the clitoris, the anterior vaginal wall near the urethra, or the labia. | Your own blood is spun to concentrate platelets, and the plasma is injected into the skin or applied over microneedled skin. | Platelet-rich fibrin is blood spun without anticoagulant so it forms a soft fibrin clot or liquid that releases growth factors slowly. |
| Evidence base | 3 PubMed-indexed studies cited below, including systematic reviews, randomised trials. | 3 PubMed-indexed studies cited below, including systematic reviews. | 4 PubMed-indexed studies cited below, including systematic reviews. |
| Suits | Possibly, within a research protocol or a gynaecologist's care, for a defined problem such as lichen sclerosus, dryness or mild stress incontinence after other options have been discussed. | Acne scarring alongside microneedling or laser, dull or thin skin, post-procedure recovery, and people who prefer an autologous product. | Thin, crepey under-eye skin or fine lines in people who want an autologous option and accept a short-lived, modest result with repeat sessions. |
| In one line | The first proper trial arrived in 2026 and was a pilot; everything sold under this name before it was marketing with a syringe. | The microneedling does much of the work; the plasma adds a little, and the setting it is done in decides the risk. | It is a biostimulant with a few months of soft volume; treated as that, it has a place after dissolving, before the next decision. |
Risks
Bruising, swelling, pain and rare infection at a sensitive site; transient changes in sensation. The commoner harm is money spent on a trademark.
In Singapore
PRP is prepared and injected by doctors in Singapore. Sexual dysfunction and incontinence deserve a gynaecological or urological assessment before any injection, and the Singapore Medical Council's advertising rules do not permit the claims made for this treatment elsewhere.
“The first proper trial arrived in 2026 and was a pilot; everything sold under this name before it was marketing with a syringe.”
Vetted protocols on the same problem
Questions
Does the O-Shot work?
Is it the same as PRP for the face or scalp?
What should I do instead?
Cite this review
Aesthetics International (2026). The 'O-Shot' and intimate PRP: does it work? Evidence, risks and verdict. https://aesthetics-international.org/treatments/o-shot-prp-intimate/ (reviewed 1 October 2026).
Editorial, unpaid and independent of any manufacturer. Verdict: Caution. See what works and what doesn't across all 153 reviews. Spotted an error or a newer study? Suggest a correction — changes are logged on the corrections page. Terms are defined in the glossary.
Have a question about this treatment?
Ask us — or ask to be matched with a practitioner in Singapore who follows evidence-based treatment. Whether it is right for you is decided at an in-person assessment, not by a review; sometimes the answer is a different treatment, or none.
WhatsApp +65 8023 7170Suggest a treatment to review
Physicians, manufacturers and readers can propose a treatment for review. Reviews are editorial and are not paid for.
[email protected]